Janovics A, Armitage R E
J S Afr Vet Assoc. 1977 Oct;48(3):155-61.
The incidence of staphylococcal mastitis was investigated in 3 large commercial Friesland herds before and after the single intracisternal administration, during the dry-period, of 1 of 4 formulations containing staphylococcal antigens, antibiotics and base alone or in combination. Results suggest that the instillation of vaccine alone and vaccine plus antibiotics into fully involuted quarters very significantly reduced the incidence of staphylococcal mastitis in the subsequent lactation. Compared with antibiotics and base, each administered alone, the vaccine reduced the number of infected quarters in the subsequent lactation by 70,52% and 79,52% respectively, whereas the corresponding values for vaccine plus antibiotics were 62,22% and 71,22% respectively. The difference in results between vaccine alone and vaccine plus antibiotics is statistically insignificant, as is the difference between the results achieved by antiobiotics and base alone. The vaccine plus antibiotics is thought to possess combined therapeutic-preventive activity. The investigation showed, however, that vaccine plus antibiotics consistently protected mastitis negative quarters against new attacks of staphylococcal mastitis during the subsequent lactation period about 1,43, 4,00 and 5,32 times more effectively than did vaccine, antibiotics and base used individually.
在3个大型商业弗里斯兰奶牛场中，对在干奶期经单次脑池内注射含葡萄球菌抗原、抗生素及单独或联合使用的赋形剂的4种制剂之一前后的葡萄球菌性乳腺炎发病率进行了调查。结果表明，向完全 involuted（此处原文可能有误，推测为 involuted，意为退化、复原）的乳腺注入单独的疫苗以及疫苗加抗生素，能非常显著地降低随后泌乳期葡萄球菌性乳腺炎的发病率。与单独使用抗生素和赋形剂相比，疫苗在随后泌乳期将感染乳腺的数量分别减少了70.52%和79.52%，而疫苗加抗生素的相应数值分别为62.22%和71.22%。单独使用疫苗和疫苗加抗生素的结果差异无统计学意义，单独使用抗生素和赋形剂的结果差异也无统计学意义。疫苗加抗生素被认为具有治疗 - 预防联合活性。然而，调查显示，在随后的泌乳期，疫苗加抗生素始终比单独使用疫苗、抗生素和赋形剂更有效地保护未患乳腺炎的乳腺免受葡萄球菌性乳腺炎新的侵袭，其保护效果约为单独使用疫苗、抗生素和赋形剂的1.43倍、4.00倍和5.32倍。
