Marriott P F, Grigor J M, Hiep A
Med J Aust. 1976 Dec 11;2(24):897-8. doi: 10.5694/j.1326-5377.1976.tb115485.x.
Most schizophrenics become in-patients in State mental hospitals, and most improve on neuroleptic medication and are rapidly discharged. The majority require long-term medication; the single most important factor in maintaining remission. This paper describes a mirror-image study using patients as their own controls, and demonstrates the highly significant differences in hospitalization before and after the administration of a depot phenothiazine. It highlights the need for vigorous and determined out-patient follow-up. It is suggested that the costs of an adequately staffed clinic are still small when compared with the costs of hospitalization. Subgroups of poor drug-responders, sex differences, variations in side effects and frequency of administration of the depot drug require further evaluation.
大多数精神分裂症患者会住进州立精神病院，大多数患者在服用抗精神病药物后病情好转并很快出院。大多数患者需要长期服药，这是维持病情缓解的最重要因素。本文描述了一项以患者自身为对照的镜像研究，并证明了长效吩噻嗪给药前后住院情况存在高度显著差异。它强调了积极且坚定的门诊随访的必要性。研究表明，与住院费用相比，人员配备充足的诊所的成本仍然很低。药物反应不佳的亚组、性别差异、副作用差异以及长效药物的给药频率需要进一步评估。
