Tisell L E, Ahlman H, Wängberg B, Kölby L, Fjälling M, Forssell-Aronsson E, Mölne J, Nilsson O
Department of Surgery, Sahlgrenska University Hospital, Göteborg, Sweden.
Br J Cancer. 1999 Mar;79(9-10):1579-82. doi: 10.1038/sj.bjc.6690251.
Ten consecutive patients with Hürthle cell lesions of the thyroid (nodule/adenoma/carcinoma) were studied by (111)In-DTPA-D-Phe1-octreotide scintigraphy. Octreotide scintigraphy localized the primary Hürthle cell tumour in eight patients as distinct areas of increased uptake of radionuclide. Two patients with Hürthle cell carcinoma, previously thyroidectomized, had their metastases visualized by octreotide scintigraphy. Northern analyses showed expression of multiple somatostain receptor subtypes. Visualization of the Hürthle cell tumour may be due to a higher expression of somatostatin receptors in the lesions than in surrounding normal thyroid tissue. The tissue/blood (111)In concentration ratios for tumour samples from five patients showed clearly higher values than observed for normal connective tissue, muscle or lymph nodes. A relatively high uptake of (111)In was also observed in goiter tissue, which may lead to misinterpretations. The main indication for octreotide scintigraphy in patients with Hürthle cell carcinoma is suspicion of metastatic disease.
对连续10例患有甲状腺许特莱细胞病变（结节/腺瘤/癌）的患者进行了¹¹¹铟 - DTPA - D - 苯丙氨酸¹奥曲肽闪烁扫描。奥曲肽闪烁扫描将8例患者的原发性许特莱细胞瘤定位为放射性核素摄取增加的明显区域。2例曾接受甲状腺切除术的许特莱细胞癌患者，其转移灶通过奥曲肽闪烁扫描得以显影。Northern印迹分析显示多种生长抑素受体亚型的表达。许特莱细胞瘤的显影可能是由于病变中生长抑素受体的表达高于周围正常甲状腺组织。5例患者肿瘤样本的组织/血液¹¹¹铟浓度比明显高于正常结缔组织、肌肉或淋巴结。在甲状腺肿组织中也观察到相对较高的¹¹¹铟摄取，这可能导致误诊。奥曲肽闪烁扫描对许特莱细胞癌患者的主要适应证是怀疑有转移性疾病。
