Pagano L, Larocca L M, Vaccario M L, Masullo C, Antinori A, Pierconti F, Tartaglione T, Cattani P, Mele L, Equitani F, Leone G
Istituto di Semeiotica Medica, Università Cattolica S. Cuore, largo Francesco Vito 1, 00168 Rome, Italy.
Haematologica. 1999 Mar;84(3):270-4.
The authors describe the cases of three patients affected by acute myeloid leukemia, in complete remission, who rapidly developed neurologic symptoms leading to death. Neither clinical characteristics, nor radiological or microbiological procedures, allowed an etiological diagnosis of the neurologic syndrome. Post-mortem examination of the brain showed both macroscopic and microscopic findings compatible with acute hemorrhagic leukoencephalitis. The difficulty in distinguishing this entity from other CNS disease-related complications (e.g. leukemia infiltration, drug toxicity, hemorrhages) should not lead to an underestimation of the true incidence of this complication. We believe that with more attention to the possibility of this complication there would probably be both a greater possibility of collecting clinical informations about the real impact of this dramatic disease and a stronger hope of finding the right treatment for it.
作者描述了3例急性髓系白血病完全缓解患者迅速出现神经症状并导致死亡的病例。临床特征、放射学或微生物学检查均无法对神经综合征做出病因诊断。脑部尸检显示大体和显微镜下表现均符合急性出血性白质脑炎。难以将该病症与其他中枢神经系统疾病相关并发症（如白血病浸润、药物毒性、出血）相区分，不应导致低估该并发症的实际发病率。我们认为，若能更多地关注这一并发症的可能性，或许更有可能收集到有关这种严重疾病实际影响的临床信息，也更有希望找到针对它的正确治疗方法。
