Sannes Ida, Harr Marianne E, Antal Ellen-Ann, Beyer Mona K, Nordengen Kaja
Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Department of Neurosurgery, Oslo University Hospital, Oslo, Norway.
Front Neurosci. 2025 Mar 31;19:1557046. doi: 10.3389/fnins.2025.1557046. eCollection 2025.
This report highlights an atypical case of acute hemorrhagic Leukoencephalitis (AHLE) in a 73-year-old male, contributing valuable insights into the disease's progression in older adults. AHLE, a rare and often fatal central nervous system disorder typically affecting younger individuals, with a median age of 33. Our patient experienced atypical subacute symptoms over 3 months, the longest duration reported, and ultimately achieved a functional outcome with a modified Rankin Scale (mRS) score of 2. A comprehensive review of 152 cases available through PubMed, revealing a 58% mortality rate with a median survival of just 2 days, and a mean mRS of 4.3, though survivor exhibited a more favorable mean mRS of 1.8. Only 6% of cases had a subacute onset of 3 weeks or more.
本报告重点介绍了一名73岁男性急性出血性白质脑炎（AHLE）的非典型病例，为该疾病在老年人中的进展提供了宝贵见解。AHLE是一种罕见且通常致命的中枢神经系统疾病，通常影响较年轻个体，中位年龄为33岁。我们的患者在3个月内出现非典型亚急性症状，这是报告中最长的持续时间，最终功能结局改良Rankin量表（mRS）评分为2分。通过PubMed对152例病例进行的全面回顾显示，死亡率为58%，中位生存期仅为2天，平均mRS为4.3，不过幸存者的平均mRS更有利，为1.8。只有6%的病例有3周或更长时间的亚急性起病。
