Epidemiological studies on the effects of hyperglycemia and improvement of glycemic control on macrovascular events in type 2 diabetes.

The relation of glycemia to coronary heart disease in subjects with type 2 diabetes is controversial. Recent data have suggested a significant relation of glycemia to cardiovascular disease in both type 2 diabetes and in subjects with impaired glucose tolerance, although the relation of glycemia to cardiovascular disease appears to be weaker than the relation of glycemia to microvascular disease.