Sjöholm A
Karolinska sjukhuset, Stockholm.
Lakartidningen. 2001 Feb 28;98(9):937-40.
In contrast to fasting glucose, postprandial hyperglycemia in type 2-diabetes has been a relatively neglected area. However, postprandial glucose spikes contribute significantly to overall glycemic control and are strongly correlated with cardiovascular morbidity and mortality (as opposed to fasting glucose). Here we review extant data implicating postprandial hyperglycemia as a tangible target for novel antidiabetic drugs with improved potential to curb not only deleterious glucose excursions, but also the macrovascular complications associated with them.
与空腹血糖相比，2型糖尿病患者的餐后高血糖一直是一个相对被忽视的领域。然而，餐后血糖峰值对整体血糖控制有显著影响，并且与心血管疾病的发病率和死亡率密切相关（与空腹血糖相反）。在此，我们回顾现有数据，这些数据表明餐后高血糖是新型抗糖尿病药物的一个切实可行的靶点，这类药物不仅有更好的潜力抑制有害的血糖波动，还能抑制与之相关的大血管并发症。
