苏丹植物提取物对HIV-1复制及HIV-1蛋白酶的抑制作用。
Inhibitory effects of Sudanese plant extracts on HIV-1 replication and HIV-1 protease.
作者信息
Hussein G, Miyashiro H, Nakamura N, Hattori M, Kawahata T, Otake T, Kakiuchi N, Shimotohno K
机构信息
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.
出版信息
Phytother Res. 1999 Feb;13(1):31-6. doi: 10.1002/(SICI)1099-1573(199902)13:1<31::AID-PTR381>3.0.CO;2-C.
Forty-eight methanol and aqueous extracts from Sudanese plants were screened for their inhibitory activity on viral replication. Nineteen extracts showed inhibitory effects on HIV-induced cytopathic effects (CPE) on MT-4 cells. The extracts were further screened against HIV-1 protease (PR) using an HPLC assay method. Of the tested extracts, the methanol extracts of Acacia nilotica (bark and pods), Euphorbia granulata (leaves), Maytenus senegalensis (stem-bark) and aqueous extracts of A. nilotica (pods) and M. senegalensis (stem-bark) showed considerable inhibitory effects against HIV-1 PR. Inhibitory principles were isolated from M. senegalensis and their activities were also discussed.
对来自苏丹植物的48种甲醇提取物和水提取物进行了病毒复制抑制活性筛选。19种提取物对HIV诱导的MT-4细胞细胞病变效应（CPE）显示出抑制作用。使用HPLC分析方法对这些提取物进一步进行抗HIV-1蛋白酶（PR）筛选。在所测试的提取物中，阿拉伯胶树（树皮和豆荚）、细叶大戟（叶）、塞内加尔美登木（茎皮）的甲醇提取物以及阿拉伯胶树（豆荚）和塞内加尔美登木（茎皮）的水提取物对HIV-1 PR显示出相当大的抑制作用。从塞内加尔美登木中分离出了抑制成分，并对其活性进行了讨论。
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