Gharzouli K, Khennouf S, Amira S, Gharzouli A
Institut de Biologie, Université Ferhat Abbas, Setif, Algeria.
Phytother Res. 1999 Feb;13(1):42-5. doi: 10.1002/(SICI)1099-1573(199902)13:1<42::AID-PTR383>3.0.CO;2-2.
The gastroprotective effect of tannic acid and the aqueous extract of Quercus ilex L. root bark, Punica granatum L. fruit peel and Artemisia herba-alba Asso leaves was investigated in the rat against ethanol-induced damage. Tannic acid, Q. ilex and P. granatum extracts gave 100% precipitation of ovine haemoglobin in vitro, whereas A. herba-alba extract was devoid of any protein-binding property. Oral administration of these plant extracts or tannic acid induced a significant decrease in gastric lesions (47.7%-76%). The observed protection was more pronounced when the test solution was given at the same time with ethanol, except for Q. ilex extract. The acid content of the stomach was significantly increased by P. granatum (368%) and A. herba-alba (251%) extracts prepared in ethanol. It is suggested that monomeric and polymeric polyphenols can strengthen the gastric mucosal barrier.
研究了鞣酸以及冬青栎根皮、石榴果皮和白蒿叶水提取物对大鼠乙醇诱导损伤的胃保护作用。鞣酸、冬青栎提取物和石榴提取物在体外能使绵羊血红蛋白100%沉淀，而白蒿提取物没有任何蛋白质结合特性。口服这些植物提取物或鞣酸可使胃损伤显著减少（47.7%-76%）。除冬青栎提取物外，当测试溶液与乙醇同时给药时，观察到的保护作用更为明显。石榴（368%）和白蒿（251%）乙醇提取物可使胃内酸含量显著增加。提示单体和聚合多酚可增强胃黏膜屏障。
