Inoue K, Koizumi S, Ueno S, Tsuda M
Div. Pharmacol., National Institute of Health Sciences, Tokyo.
Nihon Yakurigaku Zasshi. 1998 Oct;112 Suppl 1:36P-40P. doi: 10.1254/fpj.112.supplement_36.
The possible involvement of adenosine 5'-triphosphate (ATP) receptors in the function of the hippocampus and of pain transmission is discussed. Involvement of these receptors in the function of the hippocampus has been suggested by several reports. In the paper we presented the data that ATP inhibits the glutamate release in cultured hippocampal neurons. This and the report revealing that ATP protected against cell death by glutamate suggest that ATP may be playing a role in the protection of the hippocampus from over-stimulation. Microglia cells are activated by the stimulation of ATP and releases plasminogen which is well known to promote the development of mesencephalic dopaminergic neurons and enhance neurite outgrowth from explants of neocortical tissue. Therefore, ATP may have a role in repairing the damaged neuronal networks as well as protection.
本文讨论了5'-三磷酸腺苷（ATP）受体可能参与海马体功能及疼痛传递的情况。几份报告表明这些受体参与了海马体的功能。在本文中，我们展示了ATP抑制培养的海马神经元中谷氨酸释放的数据。这一发现以及另一篇揭示ATP可保护细胞免受谷氨酸诱导死亡的报告表明，ATP可能在保护海马体免受过度刺激方面发挥作用。小胶质细胞通过ATP刺激而被激活，并释放纤溶酶原，众所周知，纤溶酶原可促进中脑多巴胺能神经元的发育，并增强新皮质组织外植体的神经突生长。因此，ATP可能在修复受损神经网络以及保护方面发挥作用。
