Karan M, Vasisht K, Handa S S
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Phytother Res. 1999 Mar;13(2):95-101. doi: 10.1002/(SICI)1099-1573(199903)13:2<95::AID-PTR379>3.0.CO;2-4.
The extracts of Swertia chirata were evaluated for antihepatotoxic activity using paracetamol and galactosamine models. The methanol extract of the whole plant was found active at a dose of 100 mg/kg i.p. On fractionating this extract into chloroform soluble and butanol soluble fractions, the activity was retained in the chloroform soluble fraction which was most active at a dose level of 25 mg/kg i.p. with overall protection of 81% and 78% against paracetamol and galactosamine, respectively. The butanol soluble fraction, rich in bitter secoiridoids, was devoid of significant activity. The protective effect observed against these two hepatotoxins which are different in their mechanisms of inducing hepatotoxicity, suggests broader and non-specific protection of the liver against these two toxins by non-bitter components of Swertia chirata.
使用对乙酰氨基酚和半乳糖胺模型评估了獐牙菜提取物的抗肝毒性活性。发现全株甲醇提取物腹腔注射剂量为100mg/kg时有活性。将该提取物分离为氯仿可溶部分和丁醇可溶部分后，活性保留在氯仿可溶部分，该部分腹腔注射剂量为25mg/kg时活性最强，对乙酰氨基酚和半乳糖胺的总体保护率分别为81%和78%。富含苦味裂环烯醚萜类的丁醇可溶部分没有显著活性。观察到对这两种诱导肝毒性机制不同的肝毒素具有保护作用，表明獐牙菜的非苦味成分对肝脏具有更广泛的非特异性保护作用，使其免受这两种毒素的侵害。
