Karan M, Vasisht K, Handa S S
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Phytother Res. 1999 Feb;13(1):24-30. doi: 10.1002/(SICI)1099-1573(199902)13:1<24::AID-PTR378>3.0.CO;2-L.
The methanol extract of Swertia chirata was evaluated for antihepatotoxic activity against carbon tetrachloride induced liver toxicity in experimental rats. The extract was found to be active and on fractionation into butanol soluble and chloroform soluble fractions, the activity was traced and found more profound in the chloroform soluble fraction. The butanol soluble bitter rich fraction showed marginal activity. The results based on biochemical estimations have been expressed statistically and are additionally supported by histopathological examination of the liver of experimental rats and pentobarbitone induced sleep time studies in mice.
对印度獐牙菜的甲醇提取物进行了评估，以研究其对实验大鼠四氯化碳诱导的肝毒性的抗肝毒性活性。发现该提取物具有活性，在将其分离为丁醇可溶级分和氯仿可溶级分后，追踪到了活性，并且发现氯仿可溶级分中的活性更强。富含苦味的丁醇可溶级分显示出微弱的活性。基于生化测定的结果已进行统计学表达，并得到实验大鼠肝脏组织病理学检查和小鼠戊巴比妥诱导睡眠时间研究的进一步支持。
