[利血平对松果体切除和胸腺切除大鼠中9,10-二甲基-1,2-苯并蒽诱导肿瘤形成的影响]
[Effect of reserpine on the formation of 9,10-dimethyl-1,2-benzanthracene induced tumors in pinealectomized and thymectomized rats].
作者信息
Lapin V
出版信息
Onkologie. 1978 Feb;1(1):2-5. doi: 10.1159/000213901.
PMID:101920
Abstract
After reserpine treatment the incidence of dimethylbenzanthracene-induced tumors was found to be significantly higher in pinealectomized rats than in intact or thymectomized ones. A very high rate of DMBA-leukemia was observed in immune-deficient pinealectomized rats after reserpine administration. It is therefore suggested that the neuroendocrine disturbances due to removal of the pineal gland in the newborn animals, are latent and become evident after reserpine administration as reflected in an increased tumor incidence.
摘要
利血平处理后，发现切除松果体的大鼠中，二甲基苯并蒽诱导的肿瘤发生率显著高于完整或胸腺切除的大鼠。在给予利血平后，免疫缺陷的切除松果体大鼠中观察到非常高的二甲基苯并蒽诱导白血病发生率。因此，有人认为新生动物切除松果体引起的神经内分泌紊乱是潜伏性的，在给予利血平后变得明显，表现为肿瘤发生率增加。
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[Effect of reserpine on the formation of 9,10-dimethyl-1,2-benzanthracene induced tumors in pinealectomized and thymectomized rats].[利血平对松果体切除和胸腺切除大鼠中9,10-二甲基-1,2-苯并蒽诱导肿瘤形成的影响]
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