Cuche G, Malbert C H
Flux Digestifs et Métabolisme Protéique' Unit, Porcine Research Station, INRA, Saint Gilles, France.
Scand J Gastroenterol. 1999 Feb;34(2):149-55. doi: 10.1080/00365529950173005.
Short-chain fatty acids (SCFA) found in the ileum after caecoileal reflux might trigger a physiologic ileal brake similar that induced by ileal nutrient infusion. This study evaluates gastric emptying and motility after ileal administration of SCFA.
In eight conscious pigs gastric emptying was evaluated by double dilution (liquids) and direct measurement of duodenal effluent (liquids and solids) during ileal infusions of SCFA and isotonic and hypertonic saline. Antropyloroduodenal manometry and flow were recorded concurrently.
Ileal SCFA significantly delayed gastric emptying of liquids and solids. During SCFA infusion the emptying pattern of liquids was less pulsatile, and flow pulses had a smaller stroke volume than during isotonic saline. The antroduodenal pressure gradient was decreased, whereas pyloric tone was increased. A reduced number of antral pressure waves occurred together with an increased frequency of isolated pyloric pressure waves.
Ileal SCFA infusion delays gastric emptying of liquid and solid as a consequence of a decreased antral and increased pyloric motility.
盲肠回肠反流后在回肠中发现的短链脂肪酸（SCFA）可能触发一种类似于回肠营养输注诱导的生理性回肠制动。本研究评估回肠给予SCFA后的胃排空和动力。
在8只清醒猪中，通过双稀释法（液体）以及在回肠输注SCFA、等渗和高渗盐水期间直接测量十二指肠流出物（液体和固体）来评估胃排空。同时记录胃十二指肠测压和流量。
回肠给予SCFA显著延迟液体和固体的胃排空。在输注SCFA期间，液体的排空模式搏动性较小，与等渗盐水输注期间相比，流量脉冲的每搏量较小。胃十二指肠压力梯度降低，而幽门张力增加。胃窦压力波数量减少，同时孤立的幽门压力波频率增加。
回肠输注SCFA导致胃窦动力降低和幽门动力增加，从而延迟液体和固体的胃排空。
