Treacy P J, Jamieson G G, Dent J
University Department of Surgery, Royal Adelaide Hospital, Australia.
J Gastroenterol Hepatol. 1995 Nov-Dec;10(6):639-45. doi: 10.1111/j.1440-1746.1995.tb01363.x.
The role of the pylorus in the control of gastric emptying of liquids and digestible solids was investigated in the present study by pylorus excision in six pigs. The pylorus was left intact in another six pigs. Antro-pyloro-duodenal motility was recorded by a sleeve sensor and side holes. Liquid emptying was significantly more rapid in pylorus excised than in pylorus intact animals, during intraduodenal infusion of isosmolar dextrose (712 mL vs 107 mL), fatty acid (402 mL vs 46 mL), amino acids (752 mL vs 112 mL), 25% dextrose (392 mL vs 51 mL) and 3 normal saline (705 mL vs 157 mL). In pylorus excised animals, in contrast to pylorus intact animals, the manometric pattern of isolated pyloric pressure waves at the distal stomach was rarely seen (P < 0.05). In a second series of experiments, pylorus excised animals emptied significantly more (P < 0.04) meat over 120 min (181 g) than pylorus intact animals (80 g), but the proportion of particle sizes emptied was unaltered. In the pig, localized pyloric contractions are important for retardation of gastric emptying when nutrient or hyperosmolar solutions enter the duodenum. By contrast, the pylorus is unimportant in determining the size of solid particles emptied from the stomach.
本研究通过对六头猪进行幽门切除术，探讨了幽门在控制液体和可消化固体胃排空方面的作用。另外六头猪的幽门保持完整。通过套管传感器和侧孔记录胃窦 - 幽门 - 十二指肠的运动。在十二指肠内输注等渗葡萄糖（712毫升对107毫升）、脂肪酸（402毫升对46毫升）、氨基酸（752毫升对112毫升）、25%葡萄糖（392毫升对51毫升）和3%生理盐水（705毫升对157毫升）期间，幽门切除的猪的液体排空明显比幽门完整的动物更快。与幽门完整的动物相比，幽门切除的动物在胃远端很少见到孤立幽门压力波的测压模式（P < 0.05）。在第二系列实验中，幽门切除的动物在120分钟内排空的肉类（181克）明显多于幽门完整的动物（80克）（P < 0.04），但排空的颗粒大小比例未改变。在猪中，当营养物质或高渗溶液进入十二指肠时，局部幽门收缩对延缓胃排空很重要。相比之下，幽门在决定从胃中排空的固体颗粒大小方面并不重要。
