Sigelman J, Jakobiec F A
Ophthalmology. 1978 Aug;85(8):818-43. doi: 10.1016/s0161-6420(78)35620-7.
A retrospective clinicopathologic study of 40 patients with lymphoid lesions of the conjunctiva demonstrated the validity of current histologic criteria in predicting clinical outcome. Overall histologic architecture as well as cytologic detail must be used to differentiate benign reactive lymphoid hyperplasia from lymphoma. Lesions verified clinically as being malignant had obvious malignant cytologic features. Clinical signs of surface follicularity, multifocality, and minimal elevation suggest benignancy. All the benign lesions, on histopathologic examination, were either follicular in architecture or composed of mature lymphocytes, and were generally restricted to the substantia propria. Bilaterality and clinical recurrence do not necessarily imply a malignant disease.
一项对40例结膜淋巴样病变患者的回顾性临床病理研究证明了当前组织学标准在预测临床结果方面的有效性。必须综合整体组织学结构以及细胞学细节，以区分良性反应性淋巴样增生和淋巴瘤。临床上确诊为恶性的病变具有明显的恶性细胞学特征。表面滤泡性、多灶性和轻微隆起的临床体征提示为良性。在组织病理学检查中，所有良性病变要么结构呈滤泡性，要么由成熟淋巴细胞组成，且通常局限于固有层。双侧性和临床复发并不一定意味着是恶性疾病。
