Coleman P, Kavanagh E, Mason R M, Levick J R, Ashhurst D E
Department of Physiology, St George's Hospital Medical School, London, UK.
Histochem J. 1998 Jul;30(7):519-24. doi: 10.1023/a:1003291303380.
The synovial lining of joint capsules is important because it controls the flow of fluid into and out of the joint cavity. Physiological studies have shown that the glycosaminoglycans, particularly hyaluronan, have an important role in the control of fluid flow. The distribution of the glycosaminoglycans and proteoglycans in the synovium and subsynovium of rabbits (approximately 12 weeks old) was, therefore, determined immunohistochemically. Hyaluronan, chondroitin-4- and chondroitin-6-sulphates and keratan sulphate are present in the synovium and subsynovium; chondroitin-4-sulphate is at higher concentrations than chondroitin-6-sulphate. The core proteins of the chondroitin sulphate proteoglycans, biglycan and decorin, and of the keratan sulphate proteoglycan, fibromodulin, are also present. To date, fibromodulin has not been located in other synovial linings, and its presence corroborates that of keratan sulphate.
关节囊的滑膜内衬很重要，因为它控制着关节腔内液体的进出。生理学研究表明，糖胺聚糖，尤其是透明质酸，在控制液体流动方面起着重要作用。因此，采用免疫组织化学方法确定了约12周龄兔子滑膜和滑膜下层中糖胺聚糖和蛋白聚糖的分布。透明质酸、硫酸软骨素-4和硫酸软骨素-6以及硫酸角质素存在于滑膜和滑膜下层；硫酸软骨素-4的浓度高于硫酸软骨素-6。硫酸软骨素蛋白聚糖、双糖链蛋白聚糖和饰胶蛋白聚糖以及硫酸角质素蛋白聚糖纤维调节素的核心蛋白也存在。迄今为止，纤维调节素尚未在其他滑膜内衬中发现，它的存在证实了硫酸角质素的存在。
