Scott D, Coleman P J, Mason R M, Levick J R
Department of Physiology, St George's Hospital Medical School, London, UK.
Exp Physiol. 1997 May;82(3):603-6. doi: 10.1113/expphysiol.1997.sp004050.
The hydraulic resistance of the synovial lining of a joint is important for retention of intraarticular lubricant. The resistance has been attributed to synovial interstitial glycosaminoglycans. This was tested by depletion of hyaluronan and chondroitin sulphates from synovium in five rabbit knees in vivo under anaesthesia, using testicular hyaluronidase. The enzyme raised synovial permeability to fluid 5- to 7-fold-substantially more, in fact, than predicted by a recent model. The results prove that hyaluronan and/or chondroitin sulphate are important sources of hydraulic resistance in synovium.
关节滑膜衬里的水力阻力对于关节内润滑剂的保留很重要。这种阻力被认为归因于滑膜间质糖胺聚糖。通过在麻醉下对五只兔膝关节的滑膜进行透明质酸和硫酸软骨素的消耗来对此进行测试，使用睾丸透明质酸酶。该酶使滑膜对液体的通透性提高了5至7倍——实际上比最近一个模型预测的要高得多。结果证明，透明质酸和/或硫酸软骨素是滑膜中水力阻力的重要来源。
