Fajac I, Lacronique J, Lockhart A, Dall'Ava-Santucci J, Dusser D J
Department of Respiratory Physiology, Cochin Hospital, René Descartes University, Paris, France.
Thorax. 1998 Oct;53(10):879-81. doi: 10.1136/thx.53.10.879.
An easy and reliable method to measure potential difference (PD) in the lower airways would be of interest in the field of cystic fibrosis. We have developed silver/silver chloride (Ag/AgCl) electrodes to measure PD in the lower airways.
To validate this technique the nasal PD measured with Ag/AgCl electrodes and with conventional perfused electrodes was compared in 16 patients. The range of PD measured with Ag/AgCl electrodes in the lower airways during fibreoptic bronchoscopy was determined in 14 adult patients and in nine the reproducibility of this technique was examined.
Nasal PD values measured with Ag/AgCl and perfused electrodes were highly correlated (r = 0.985, p < 0.0001) and the limits of agreement (mean +/- 2SD of the difference) between the two methods were -1.91 mV and 1.53 mV. In the lower airways a progressive and slight decrease in PD values with decreasing airway diameter was observed in most patients. The mean (2SD) of the differences between the two tracheal measurements was 0.21 (1.73) mV.
The use of Ag/AgCl electrodes gives a reliable and reproducible measurement of PD in the lower airways in humans.
在囊性纤维化领域，一种用于测量下呼吸道电位差（PD）的简便可靠方法将备受关注。我们已研发出银/氯化银（Ag/AgCl）电极来测量下呼吸道的PD。
为验证该技术，在16例患者中比较了用Ag/AgCl电极和传统灌注电极测量的鼻腔PD。在14例成年患者中确定了纤维支气管镜检查期间用Ag/AgCl电极测量的下呼吸道PD范围，并在9例患者中检查了该技术的可重复性。
用Ag/AgCl电极和灌注电极测量的鼻腔PD值高度相关（r = 0.985，p < 0.0001），两种方法之间的一致性界限（差异的均值±2SD）为-1.91 mV和1.53 mV。在大多数患者中，在下呼吸道观察到随着气道直径减小，PD值逐渐轻微下降。两次气管测量之间差异的均值（2SD）为0.21（1.73）mV。
使用Ag/AgCl电极可对人体下呼吸道的PD进行可靠且可重复的测量。
