Lange V
Psychiatr Clin (Basel). 1976;9(1):32-44.
To analyze the biological pathways of the genetical activity in psychoses is growing more and more to an important goal. The research in this field should be started on the assumption of a multifactorial hereditary system controlling the somatic base of mental illness in a specific way as can be argued from twin and family studies. Screening the present data, there is strong evidence that the metabolism of affective psychoses is characterized by quantitative deviations only concerning the 5-hydroxytryptamine and norepinephrine turnover particularly. The biochemical findings in schizophrenic psychoses are suspicious for qualitative abnormities too. There are some indications of toxic products in the catecholamine metabolism and of antibodies against brain substances. All these disturbances could be caused by structural gene mutants or by mutations of the genetical regulatory system changing the sensitivity for the environmental stimulus. The simultaneous investigation of simple inherited serum groups is described as a useful tool for biological marking of the responsible genotypes.
分析精神病遗传活动的生物学途径正日益成为一个重要目标。从双胞胎和家族研究可以推断，该领域的研究应基于多因素遗传系统的假设展开，该系统以特定方式控制精神疾病的躯体基础。筛选现有数据发现，有强有力的证据表明，情感性精神病的代谢仅在5-羟色胺和去甲肾上腺素周转方面存在定量偏差。精神分裂症性精神病的生化发现也怀疑存在定性异常。儿茶酚胺代谢中有一些有毒产物的迹象以及针对脑物质的抗体。所有这些紊乱可能由结构基因突变或遗传调节系统的突变引起，这些突变改变了对环境刺激的敏感性。对简单遗传血清组的同步研究被认为是对相关基因型进行生物学标记的有用工具。
