Guelfi J D, Mialet J P
Encephale. 1981;7(5):569-600.
Most of the present biological hypothesis postulate biogenic amines disorders in schizophrenia: transmethylation and dopaminergic theory. Other systems which can modulate this neuro-transmitter, specially in the mesolimbic dopaminergic system, may be concerned: nor-epinephrine, serotonin or endorphins. A dysfunction in arousal and cerebral dominance has been described by the quantitative electroencephalography. Other electrophysiological studies are consistent with these results; they indicate an impairment of the level of arousal to which the disorders of attention and adaptation could be related. In affective psychoses the major hypothesis bear on norepinephrine or serotonin disorders. But other substances may have a role: acetylcholine and dopamine as well as electrolytic modifications of cell membranes or immunological or neuroendocrine disturbances. This biological and physiological fundamental research has numerous practical consequences as the discovery of compounds with a more specific effect, the research of biological and biochemical diagnostic indices, or the drawing up of biological indices for neuroleptics, antidepressants or lithium sensitivity.
转甲基化和多巴胺能理论。其他能够调节这种神经递质的系统，特别是中脑边缘多巴胺能系统，可能也与之相关：去甲肾上腺素、血清素或内啡肽。定量脑电图已描述了觉醒和大脑优势功能的障碍。其他电生理研究与这些结果一致；它们表明觉醒水平受损，注意力和适应障碍可能与之相关。在情感性精神病中，主要假说涉及去甲肾上腺素或血清素紊乱。但其他物质可能也起作用：乙酰胆碱、多巴胺以及细胞膜的电解质改变或免疫或神经内分泌紊乱。这项生物学和生理学基础研究有许多实际应用，如发现具有更特效的化合物、研究生物学和生化诊断指标，或制定抗精神病药、抗抑郁药或锂敏感性的生物学指标。
