Veeramachaneni D N, Vandewoude S
Department of Physiology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523-1683, USA.
Int J Androl. 1999 Apr;22(2):97-101. doi: 10.1046/j.1365-2605.1999.00154.x.
Simultaneous occurrence of a well-demarcated interstitial cell tumour and an intratubular seminoma-like tumour, which was beginning to invade peritubular areas, in the contralateral testes of a 3-year-old Dutch-Belted rabbit is described. Morphological hallmarks of carcinoma in situ, which have not been reported previously for the rabbit, were observed in association with the seminoma. These observations indicate that carcinoma in situ, preceding a seminoma-like tumour, occurs in the rabbit and that the rabbit may serve as a practically useful animal model for studying testicular germ cell neoplasia.
本文描述了一只3岁荷兰带兔对侧睾丸中同时出现界限清晰的间质细胞瘤和管内精原细胞瘤样肿瘤，后者已开始侵犯睾丸周围区域。在精原细胞瘤中观察到原位癌的形态学特征，这在兔子中此前尚未见报道。这些观察结果表明，原位癌先于精原细胞瘤样肿瘤在兔子中发生，并且兔子可能成为研究睾丸生殖细胞肿瘤的实用动物模型。
