Han Z S, Zhang E T, Craig A D
Division of Neurobiology, Barrow Neurological Institute, Phoenix, Arizona 85013, USA.
Nat Neurosci. 1998 Jul;1(3):218-25. doi: 10.1038/665.
Pain and temperature stimuli activate neurons of lamina I within the dorsal horn of the spinal cord, and although these neurons can be classified into three basic morphological types and three major physiological classes, earlier studies did not establish a structure/function correlation between their morphology and their physiological responses. We recorded and intracellularly labeled 38 cat lamina I neurons. All 12 fusiform cells were nociceptive-specific, responsive only to pinch and/or heat. All 11 pyramidal cells were thermoreceptive-specific, responsive only to innocuous cooling. Of ten multipolar cells, six were polymodal, responsive to heat, pinch and cold, and four were nociceptive-specific. Five unclassified cells had features consistent with this pattern. These results support the view that central pain and temperature pathways contain anatomically discrete sets of modality-selective neurons.
疼痛和温度刺激会激活脊髓背角I层的神经元，尽管这些神经元可分为三种基本形态类型和三大生理类别，但早期研究并未在其形态与生理反应之间建立起结构/功能相关性。我们记录并对38个猫I层神经元进行了细胞内标记。所有12个梭形细胞都是伤害性特异性的，仅对捏和/或热有反应。所有11个锥体细胞都是温度感受特异性的，仅对无害冷却有反应。在10个多极细胞中，6个是多模式的，对热、捏和冷有反应，4个是伤害性特异性的。5个未分类的细胞具有与该模式一致的特征。这些结果支持这样一种观点，即中枢性疼痛和温度传导通路包含在解剖学上离散的模式选择性神经元组。
