Agostini H T, Ryschkewitsch C F, Singer E J, Baumhefner R W, Stoner G L
Neurotoxicology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.
J Hum Virol. 1998 Mar-Apr;1(3):200-6.
Previous studies have shown that strains of human polyomavirus JC (JCV) of Asian origin (type 2) are much more highly represented in progressive multifocal leukoencephalopathy (PML) brain than would be expected from their frequency of excretion in urine samples of a comparable control group. The present studies were designed to test whether one subtype of type 2 was preferentially elevated.
STUDY DESIGN/METHODS: The statistical relation between JCV subtypes represented in PML brain tissue from 51 probands and those in urine samples from 115 control individuals was examined.
The proportion of the JCV subtype 2B in PML brain (36%) was highly significantly increased relative to its occurrence in control urine samples (5.9%; P < .001). Type 1 and its subtypes were not different in the PML brain and control urine cohorts. The number of type 4 strains in PML brains was reduced, although the difference did not reach statistical significance (P = .08).
The results predict that the human immunodeficiency virus (HIV)-positive individuals at highest risk of PML infection are those carrying the JCV genotype known as type 2B. Prospective studies will be required to confirm this finding.
先前的研究表明，亚洲起源的人多瘤病毒JC（JCV）毒株（2型）在进行性多灶性白质脑病（PML）脑内的占比，比在可比对照组尿液样本中的排泄频率所预期的要高得多。本研究旨在测试2型的一个亚型是否有优先升高的情况。
研究设计/方法：检测了51名先证者的PML脑组织中JCV亚型与115名对照个体尿液样本中JCV亚型之间的统计学关系。
PML脑内JCV 2B亚型的比例（36%）相对于其在对照尿液样本中的出现率（5.9%）显著大幅增加（P <.001）。1型及其亚型在PML脑组和对照尿液组中无差异。PML脑中4型毒株的数量减少，尽管差异未达到统计学意义（P = 0.08）。
结果预测，感染PML风险最高的人类免疫缺陷病毒（HIV）阳性个体是那些携带被称为2B型JCV基因型的个体。需要进行前瞻性研究来证实这一发现。
