Dubois V, Moret H, Lafon M E, Brodard V, Icart J, Ruffault A, Guist'hau O, Buffet-Janvresse C, Abbed K, Dussaix E, Ingrand D
Virology Laboratory, University Bordeaux 2, Bordeaux, France.
J Infect Dis. 2001 Jan 15;183(2):213-217. doi: 10.1086/317927. Epub 2000 Nov 29.
JC virus (JCV) induces progressive multifocal leukoencephalopathy (PML), especially in human immunodeficiency virus (HIV)-infected patients. Although JCV genotypes have primarily been associated with geographic patterns, a distinctive neuropathogenicity was recently attributed to genotype 2. A multicenter study was conducted to describe the distribution of JCV genotypes in France and to investigate correlations between genotypes and PML. Genotypes were determined by sequencing 494 bp in the VP1 capsid gene. Peripheral JCV was studied in 65 urine samples from 43 HIV-infected patients and from 22 control subjects. Genotypes 1, 4, 2, and 3 were detected in 52.3%, 30.8%, 12.3%, and 4.6% of the samples, respectively. In 56 brain or cerebrospinal fluid samples, PML-associated JCV of genotypes 1, 2, 4, and 3 was found in 66%, 19.7%, 8.9%, and 5.4%, respectively. Infection with JCV genotypes 1 or 2 was correlated with PML (odds ratio, 3.29). On the other hand, infection with JCV genotype 4 could represent a lower risk for PML.
JC病毒（JCV）可引发进行性多灶性白质脑病（PML），尤其是在感染人类免疫缺陷病毒（HIV）的患者中。尽管JCV基因型主要与地理分布模式相关，但最近有研究表明基因型2具有独特的神经致病性。本研究开展了一项多中心研究，以描述法国JCV基因型的分布情况，并探究基因型与PML之间的相关性。通过对VP1衣壳基因中的494bp进行测序来确定基因型。研究了43例HIV感染患者和22例对照受试者的65份尿液样本中的外周JCV。样本中分别检测到基因型1、4、2和3的比例为52.3%、30.8%、12.3%和4.6%。在56份脑或脑脊液样本中，分别有66%、19.7%、8.9%和5.4%的样本发现与PML相关的JCV基因型1、2、4和3。感染JCV基因型1或2与PML相关（优势比，3.29）。另一方面，感染JCV基因型4可能意味着发生PML的风险较低。
