意大利若干地区卡波西肉瘤相关疱疹病毒/人类疱疹病毒8型的血清流行率。

Seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 in several regions of Italy.

作者信息

Calabrò M L, Sheldon J, Favero A, Simpson G R, Fiore J R, Gomes E, Angarano G, Chieco-Bianchi L, Schulz T F

机构信息

Department of Oncology and Surgical Sciences, University of Padova, Italy.

出版信息

J Hum Virol. 1998 Mar-Apr;1(3):207-13.

PMID:10195244

Abstract

OBJECTIVE

To study the seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/HHV-8) in 779 Italian blood donors.

STUDY DESIGN/METHODS: Sera were tested for antibodies to a latency-associated nuclear antigen (LANA) and a capsid related protein encoded by ORF65.

RESULTS

Among all Italian donors, 17.7% and 18.7% had antibodies to LANA and ORF65 protein, respectively, and 24.1% had antibodies to at least one antigen. KSHV/HHV-8 seroprevalence was higher in the Po valley and in Sardinia than close to the sub-Alpine Veneto region, Tuscany, or Apulia. KSHV/HHV-8 seroprevalence was almost equally distributed between men and women but increased in the older age groups.

CONCLUSIONS

The regional differences and age distribution in seroprevalence agree partially with the incidence of classic KS in Italy. The rarity of classic KS in KSHV/HHV-8-infected subjects and the equal gender distribution of seroprevalence suggest that other cofactors may contribute to KS development in human immunodeficiency virus type 1 (HIV-1)-uninfected individuals.

摘要

目的

研究779名意大利献血者中卡波西肉瘤相关疱疹病毒/人类疱疹病毒8型（KSHV/HHV-8）的血清流行率。

研究设计/方法：检测血清中针对潜伏相关核抗原（LANA）和由ORF65编码的衣壳相关蛋白的抗体。

结果

在所有意大利献血者中，分别有17.7%和18.7%的人对LANA和ORF65蛋白有抗体，24.1%的人对至少一种抗原有抗体。波河流域和撒丁岛的KSHV/HHV-8血清流行率高于靠近亚高山威尼托地区、托斯卡纳或普利亚地区。KSHV/HHV-8血清流行率在男性和女性中分布几乎相同，但在老年人群中有所增加。