Jamner L D, Leigh H
Department of Psychology and Social Behavior, University of California, Irvine 92697-7085, USA.
Psychiatry Res. 1999 Jan 18;85(1):17-31. doi: 10.1016/s0165-1781(98)00134-6.
Hyperactivity of endogenous opioid systems has been postulated to mediate the associations between defensive/repressive coping styles, enhanced stress responsivity, and reduced immunocompetence. Study 1 examined whether repressive/defensive coping would be associated with greater sensitivity to opioid antagonism. Judgments of the painfulness of ascending series of electrocutaneous stimulation applied to the forearm were determined before and after the administration of naloxone and placebo in 38 men and 42 women. All subjects were healthy with a mean age of 32.9 years. Naloxone (10 mg i.v.) and placebo were administered in double-blind fashion and counterbalanced. Subjects were classified as High- and Low-defensive and repressive copers on the basis of scores on the Marlowe-Crowne Social Desirability Scale and the Balanced Inventory of Desirable Responding, respectively. High Self-Deception was associated with naloxone-induced hyperalgesia, whereas no effects of naloxone on pain ratings were observed in low-Self-Deceptive subjects. In Study 2, resting plasma beta-endorphin levels were found to be positively correlated with defensiveness in men (n = 26), but not women (n = 44). Study 3 examined 82 healthy subjects (mean age = 28.7 years). Beta-endorphin/defensiveness correlations were found to be greater following, compared to prior to, electrical nociceptive stimulation in men (n = 49), but unrelated in women (n = 33). These findings are consistent with the hypothesized endorphinergic dysregulation associated with repressive/defensive coping styles and are discussed in terms of the immuno-regulatory implications of such a dysregulation.
内源性阿片系统的功能亢进被认为是防御性/压抑性应对方式、增强的应激反应性和免疫能力降低之间关联的介导因素。研究1检验了压抑性/防御性应对是否与对阿片拮抗作用的更高敏感性相关。在38名男性和42名女性中，于静脉注射纳洛酮和安慰剂前后，测定对施加在前臂的一系列递增电皮肤刺激的疼痛程度判断。所有受试者均健康，平均年龄为32.9岁。纳洛酮（10毫克静脉注射）和安慰剂以双盲方式给药并进行了平衡处理。受试者分别根据马洛-克劳恩社会期望量表和期望反应平衡量表的得分被分类为高防御性和低防御性及压抑性应对者。高自我欺骗与纳洛酮诱导的痛觉过敏相关，而在低自我欺骗的受试者中未观察到纳洛酮对疼痛评分的影响。在研究2中，发现静息血浆β-内啡肽水平在男性（n = 26）中与防御性呈正相关，但在女性（n = 44）中并非如此。研究3对82名健康受试者（平均年龄 = 28.7岁）进行了检查。发现男性（n = 49）在电伤害性刺激后β-内啡肽/防御性的相关性比刺激前更大，但在女性（n = 33）中两者无关。这些发现与假设的与压抑性/防御性应对方式相关的内啡肽能调节异常一致，并从这种调节异常的免疫调节意义方面进行了讨论。
