Jamner L D, Schwartz G E, Leigh H
Department of Psychology, California State University, San Bernardino 92407.
Psychosom Med. 1988 Nov-Dec;50(6):567-75. doi: 10.1097/00006842-198811000-00002.
The opioid peptide hypothesis of repression (1) predicts that repressive coping is associated with increased functional endorphin levels in the brain, which can result in decreased immunocompetence and hyperglycemia. In a random sample of 312 patients seen at a Yale Medical School outpatient clinic, significant main effects of coping style were found for monocyte and eosinophile counts, serum glucose levels, and self-reports of medication allergies. Specifically, repressive and defensive high-anxious patients demonstrated significantly decreased monocyte counts. In addition, repressive coping was associated with elevated eosinophile counts, serum glucose levels, and self-reported reactions to medications. This behavioral, immunologic, and endocrine profile is consistent with the opioid peptide hypothesis, which provides an integrative framework for relating the attenuated emotional experience of pain and distress characteristic of repressive coping with reduced resistance to infectious and neoplastic disease.
压抑的阿片肽假说（1）预测，压抑应对与大脑中内啡肽功能水平升高有关，这可能导致免疫能力下降和血糖升高。在耶鲁医学院门诊随机抽取的312名患者样本中，应对方式对单核细胞和嗜酸性粒细胞计数、血糖水平以及药物过敏的自我报告有显著的主效应。具体而言，压抑型和防御型高焦虑患者的单核细胞计数显著降低。此外，压抑应对与嗜酸性粒细胞计数升高、血糖水平升高以及自我报告的药物反应有关。这种行为、免疫和内分泌特征与阿片肽假说一致，该假说为将压抑应对所特有的减轻疼痛和痛苦的情感体验与对传染病和肿瘤疾病抵抗力降低联系起来提供了一个综合框架。
