一项关于缓冲利多卡因用于儿童和成人单纯性裂伤局部麻醉浸润的随机对照试验。

A randomized controlled trial of buffered lidocaine for local anesthetic infiltration in children and adults with simple lacerations.

作者信息

Fatovich D M, Jacobs I G

机构信息

Department of Emergency Medicine, Swan District Hospital, Middle Swan WA, Australia.

出版信息

J Emerg Med. 1999 Mar-Apr;17(2):223-8. doi: 10.1016/s0736-4679(98)00157-7.

DOI:10.1016/s0736-4679(98)00157-7

PMID:10195475

Abstract

This study assessed the efficacy of buffered lidocaine in children and adults for the repair of simple lacerations. We compared plain lidocaine (PL) with buffered lidocaine (BL) in a prospective, randomized, double-blind, placebo controlled trial. Children had a 10-point pain score assessed by a nurse using predetermined behavior criteria, and a visual analog pain score (VAS) as perceived by the parent. Adult visual analog scores were self reported. In 135 adults, the median VAS was 2.1 for PL and 2.0 for BL. In 136 children, the median nurse-rated pain score was 4.5 for both PL and BL. The parent's median VAS was 4.5 for PL and 4.0 for BL. In contrast to previous studies, we conclude that buffered lidocaine does not reduce infiltration pain in children or adults.

摘要

本研究评估了缓冲利多卡因在儿童和成人中用于单纯性伤口缝合的疗效。我们在一项前瞻性、随机、双盲、安慰剂对照试验中，将普通利多卡因（PL）与缓冲利多卡因（BL）进行了比较。儿童由护士根据预先确定的行为标准评估10分制疼痛评分，同时由家长评估视觉模拟疼痛评分（VAS）。成人的视觉模拟评分由其自行报告。在135名成人中，PL组的VAS中位数为2.1，BL组为2.0。在136名儿童中，PL组和BL组护士评定的疼痛评分中位数均为4.5。家长评定的PL组VAS中位数为4.5，BL组为4.0。与之前的研究不同，我们得出结论，缓冲利多卡因并不能减轻儿童或成人的浸润性疼痛。