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用于简单裂伤修复的局部麻醉剂:缓冲利多卡因与普通利多卡因的比较。

Buffered versus plain lidocaine as a local anesthetic for simple laceration repair.

作者信息

Bartfield J M, Gennis P, Barbera J, Breuer B, Gallagher E J

机构信息

Department of Ambulatory Care, Bronx Municipal Hospital Center, New York 10461.

出版信息

Ann Emerg Med. 1990 Dec;19(12):1387-9. doi: 10.1016/s0196-0644(05)82603-4.

Abstract

STUDY OBJECTIVE

Buffered lidocaine was compared with plain lidocaine as a local anesthetic for simple lacerations.

DESIGN

Randomized, double-blind, prospective clinical trial.

SETTING

Urban emergency department.

TYPE OF PARTICIPANTS

Ninety-one adult patients with simple linear lacerations were enrolled. Patients with allergy to lidocaine and patients with an abnormal mental status were excluded.

INTERVENTIONS

Each wound edge was anesthetized with either plain or buffered lidocaine using a randomized, double-blind protocol. The pain of infiltration was measured with a previously validated visual analog pain scale.

MEASUREMENTS AND MAIN RESULTS

Analysis of pooled data and paired data (using patients as their own controls) revealed that infiltrating buffered lidocaine was significantly less painful than plain lidocaine (P = .03 and P = .02, respectively). There was no significant difference in the anesthetic effectiveness of the two agents during suturing.

CONCLUSION

Buffered lidocaine is preferable to plain lidocaine as a local anesthetic agent for the repair of simple lacerations.

摘要

研究目的

比较缓冲利多卡因与普通利多卡因作为简单裂伤局部麻醉剂的效果。

设计

随机、双盲、前瞻性临床试验。

地点

城市急诊科。

参与者类型

纳入91例患有简单线性裂伤的成年患者。排除对利多卡因过敏的患者和精神状态异常的患者。

干预措施

采用随机双盲方案,用普通或缓冲利多卡因对每个伤口边缘进行麻醉。使用先前验证过的视觉模拟疼痛量表测量浸润疼痛。

测量指标及主要结果

汇总数据分析和配对数据分析(以患者自身作为对照)显示,浸润缓冲利多卡因的疼痛明显低于普通利多卡因(P值分别为0.03和0.02)。两种药物在缝合过程中的麻醉效果无显著差异。

结论

作为简单裂伤修复的局部麻醉剂,缓冲利多卡因优于普通利多卡因。

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