Nakamura Y, Yanagawa H, Hoshi K, Yoshino H, Urata J, Sato T
Department of Public Health, Jichi Medical School, Minamikawachi, Tochigi, Japan.
Int J Epidemiol. 1999 Feb;28(1):130-4. doi: 10.1093/ije/28.1.130.
The objective of this study is to clarify the incidence rate of Creutzfeldt-Jakob disease (CJD) during the last decade in Japan.
A nationwide mail survey was conducted in all hospitals with a minimum bed capacity of 100 and having at least one of three departments: neurology, psychiatry, and neuropathology. The survey required the patient's sex, date of birth, date of diagnosis, diagnostic criteria, medical history and CJD incidence in the family.
From 493 hospitals throughout the country, 821 patients with CJD were reported from January 1985 through March 1996. The annual incidence rate was 0.49 per million population for males and 0.68 for females. The age-specific incidence rate was highest among those 70-79 years of age, followed by the 60-69, and 50-59 age groups. The incidence and mortality increased during the observed period; however, the incidence rate among younger generations did not rise.
A nationwide incidence survey of CJD in Japan revealed the incidence and distribution of the disease over the recent decade. It was found that the incidence and mortality rates had increased during the observed period.
本研究的目的是阐明日本过去十年中克雅氏病（CJD）的发病率。
对全国所有床位至少100张且设有神经科、精神科和神经病理学三个科室中至少一个科室的医院进行了邮件调查。调查内容包括患者的性别、出生日期、诊断日期、诊断标准、病史以及家族中CJD的发病率。
在1985年1月至1996年3月期间，全国493家医院共报告了821例CJD患者。男性的年发病率为每百万人口0.49例，女性为0.68例。年龄特异性发病率在70 - 79岁人群中最高，其次是60 - 69岁和50 - 59岁年龄组。在观察期内，发病率和死亡率有所上升；然而，年轻一代的发病率并未上升。
日本全国范围内的CJD发病率调查揭示了该疾病在近十年中的发病率和分布情况。研究发现，在观察期内发病率和死亡率有所增加。
