天蓝色链霉菌A3(2)在铁限制培养基中放线紫红素的产生。
Actinorhodin production by Streptomyces coelicolor A3(2) in iron-restricted media.
作者信息
Coisne S, Béchet M, Blondeau R
机构信息
Laboratoire de Microbiologie, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France.
出版信息
Lett Appl Microbiol. 1999 Mar;28(3):199-202. doi: 10.1046/j.1365-2672.1999.00509.x.
Production of the polyketide antibiotic actinorhodin by Streptomyces coelicolor A3(2) was investigated using a defined medium with or without iron supplementation. Iron limitation was found to enhance the intracellular production and export of the pigmented antibiotic. The effect of iron deficiency was particularly pronounced when the bacterium was grown with nitrate instead of ammonium. Analysis of the excreted pigment led to the identification of the lactone form of actinorhodin, gamma-actinorhodin.
使用添加或不添加铁元素的特定培养基，对天蓝色链霉菌A3(2)产生聚酮类抗生素放线紫红素的情况进行了研究。发现铁限制可增强这种有色抗生素的细胞内产生及分泌。当细菌以硝酸盐而非铵盐为氮源生长时，缺铁的影响尤为显著。对分泌色素的分析确定了放线紫红素的内酯形式，即γ-放线紫红素。
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