Coelho C M, Zucoloto S
Department of Dentistry, University of Ribeirão Preto, São Paulo, Brazil.
Int J Prosthodont. 1999 Jan-Feb;12(1):73-7.
Denture-induced fibrous inflammatory hyperplasia (FIH) occurs around the borders of an ill-fitting denture. There has been no report in the literature concerning epithelial proliferative activity in FIH. The purpose of this study was to observe the labeling of proliferating cell nuclear antigen (PCNA) and evaluate its clinicopathologic results.
The labeling index (LI) was assessed by using the PCNA, a nuclear protein synthesized mainly in the G1-S stages of the cell cycle that could be detected immunohistochemically by the monoclonal antibody PC10. The PCNA LI was assessed in FIH specimens, in clinically normal specimens 1 cm from the FIH margin (adjacent group), and in clinically normal specimens located at least 2 cm from the adjacent group; the last were considered the control group.
The mean PCNA LI values in the basal, parabasal, and overall epithelial layers were similar in FIH and in the adjacent group and were significantly higher than in the control group.
These data support the importance of the surgical treatment of FIH with wide excision (about 1 cm) since the clinically normal tissue around the lesion could be histologically altered.
义齿性纤维炎性增生（FIH）发生于不合适义齿的边缘。文献中尚无关于FIH上皮增殖活性的报道。本研究的目的是观察增殖细胞核抗原（PCNA）的标记情况并评估其临床病理结果。
标记指数（LI）通过使用PCNA进行评估，PCNA是一种主要在细胞周期的G1-S期合成的核蛋白，可通过单克隆抗体PC10进行免疫组织化学检测。在FIH标本、距FIH边缘1 cm的临床正常标本（相邻组）以及距相邻组至少2 cm的临床正常标本中评估PCNA LI；最后一组被视为对照组。
FIH组和相邻组的基底、副基底及整个上皮层的平均PCNA LI值相似，且显著高于对照组。
这些数据支持对FIH进行广泛切除（约1 cm）手术治疗的重要性，因为病变周围的临床正常组织可能在组织学上发生改变。
