Thomas G A
Department of Prosthetic Dentistry, University of Sydney, Surry Hills.
Aust Prosthodont J. 1991;5:29-34.
Involucrin is a major structural protein specific to the cross-linked cell envelope found in the stratum corneum of stratified squamous epithelium. This protein is considered to be an excellent immunohistochemical marker of normal squamous differentiation. Detection of variations to the patterns of immunostaining for involucrin may also be of value in the differential diagnosis between benign and malignant lesions. Previous studies of involucrin expression in oral mucosa have failed to clarify the effect of chronic inflammatory change upon the patterns of immunoreactivity. This study investigated involucrin staining patterns in fibrous inflammatory hyperplasia of oral mucous membrane (FIH). The results suggest that in FIH an altered pattern of involucrin immunostain occurs in areas of severe inflammatory change. This may reflect changes to the pattern of squamous differentiation in this tissue.
兜甲蛋白是一种主要的结构蛋白，特异性存在于复层鳞状上皮角质层中的交联细胞包膜。这种蛋白质被认为是正常鳞状分化的优秀免疫组织化学标志物。检测兜甲蛋白免疫染色模式的变化在良性和恶性病变的鉴别诊断中也可能具有价值。先前关于口腔黏膜中兜甲蛋白表达的研究未能阐明慢性炎症变化对免疫反应模式的影响。本研究调查了口腔黏膜纤维性炎性增生（FIH）中的兜甲蛋白染色模式。结果表明，在FIH中，严重炎症变化区域会出现兜甲蛋白免疫染色模式改变。这可能反映了该组织中鳞状分化模式的变化。
