Neckameyer W S
Department of Pharmacological and Physiological Science, St. Louis University School of Medicine, MO 63104, USA.
J Neurogenet. 1998 Mar;12(2):101-14. doi: 10.3109/01677069809167259.
Newly eclosed Drosophila melanogaster flies were systemically depleted of dopamine by feeding an inhibitor of the biosynthetic enzyme, tyrosine hydroxylase, and analyzed for abnormalities in courtship behavior. Dopamine-depleted females were significantly less receptive to males than were control females, although males were strongly attracted to treated females. The decrease in receptivity was reversed by the addition of L-DOPA (the product of the tyrosine hydroxylation reaction) to food containing the inhibitor. Male courtship behaviors were unaffected by this treatment. Female receptivity may be regulated via interactions with hormonal pathways, since depletion of dopamine levels via inhibition of tyrosine hydroxylase activity in Drosophila melanogaster adult females has established that dopamine is required for normal ovarian maturation and fecundity.
通过喂食生物合成酶酪氨酸羟化酶的抑制剂，使新羽化的黑腹果蝇全身多巴胺耗竭，并分析其求偶行为异常情况。多巴胺耗竭的雌性果蝇对雄性的接受度明显低于对照雌性果蝇，尽管雄性果蝇会被经处理的雌性果蝇强烈吸引。在含有抑制剂的食物中添加L-多巴（酪氨酸羟化反应的产物）可逆转接受度的降低。这种处理对雄性求偶行为没有影响。雌性果蝇的接受度可能通过与激素途径的相互作用来调节，因为在黑腹果蝇成年雌性中通过抑制酪氨酸羟化酶活性来降低多巴胺水平已证实，多巴胺是正常卵巢成熟和繁殖力所必需的。
