Morrison H I, Ellison L F, Taylor G W
Cancer Bureau, Health Canada, Canada.
J Cardiovasc Risk. 1999 Feb;6(1):7-11. doi: 10.1177/204748739900600102.
Recent reports have implicated periodontal disease as a risk factor for coronary heart disease (CHD).
A retrospective cohort study was conducted using participants in the 1970-1972 Nutrition Canada Survey (NCS). The mortality experience of male and female NCS participants aged 35-84 years without self-reported CHD (n = 10,368) or cerebrovascular disease (CVD) (n = 11,251) was determined through 1993. The relation between dental health and the risk of fatal CHD and CVD was assessed using Poisson regression modeling.
In total, 466 CHD and 210 CVD deaths were observed; missing confounder data reduced these numbers to 416 CHD and 182 CVD deaths. Adjusted for age, sex, diabetes status, serum total cholesterol, smoking, hypertensive status, and province, we found a statistically significant association between periodontal disease and risk of fatal CHD. Rate ratios (RR) of 2.15 [95% confidence interval (CI) 1.25-3.72) and 1.90 (95% CI 1.17-3.10) were observed for severe gingivitis and edentulous status, respectively. Non-statistically significantly increased RRs of 1.81 and 1.63 were observed for severe gingivitis and edentulous status for CVD.
These data indicate that poor dental health is associated with an increased risk of fatal CHD.
最近的报告表明牙周病是冠心病（CHD）的一个风险因素。
利用1970 - 1972年加拿大营养调查（NCS）的参与者进行了一项回顾性队列研究。确定了年龄在35 - 84岁之间、无自我报告的冠心病（n = 10,368）或脑血管疾病（CVD）（n = 11,251）的男性和女性NCS参与者至1993年的死亡情况。使用泊松回归模型评估牙齿健康与致命性冠心病和CVD风险之间的关系。
总共观察到466例冠心病死亡和210例CVD死亡；混杂因素数据缺失使这些数字分别降至416例冠心病死亡和182例CVD死亡。在对年龄、性别、糖尿病状况、血清总胆固醇、吸烟、高血压状况和省份进行调整后，我们发现牙周病与致命性冠心病风险之间存在统计学上的显著关联。重度牙龈炎和无牙状态的率比（RR）分别为2.15 [95%置信区间（CI）1.25 - 3.72]和1.90（95% CI 1.17 - 3.10）。对于CVD，重度牙龈炎和无牙状态的RR分别非统计学显著增加至1.81和1.63。
这些数据表明牙齿健康状况不佳与致命性冠心病风险增加有关。
