Hardan Louis, Matta Anthony, Bourgi Rim, Cuevas-Suárez Carlos Enrique, Devoto Walter, Zarow Maciej, Jakubowicz Natalia, Campelo-Parada Francisco, Elbaz Meyer, Carrié Didier, Roncalli Jerome
Department of Restorative Dentistry, School of Dentistry, Saint-Joseph University, 1107 2180 Beirut, Lebanon.
Department of Cardiology, Institute CARDIOMET, University Hospital of Toulouse, 31059 Toulouse, France.
Rev Cardiovasc Med. 2023 Jun 6;24(6):159. doi: 10.31083/j.rcm2406159. eCollection 2023 Jun.
The link between dental, infective and obstructive cardiovascular diseases is debatable.
To systematically review the literature to assess the association between dental conditions and development of cardiovascular disease.
The systematic review was conducted following the PRISMA guidelines using PubMed (Medline), Web of Science, Scopus, EMBASE and SciELO.
Out of 6680 records, 82 articles were eligible for inclusion after reviewing titles and abstracts. No association between dental disease and cardiovascular disease has been observed in 10 studies while a potential link has been suggested by the remaining trials. Tooth loss and periodontitis are the main evaluated oral conditions while coronary artery disease, stroke, atherosclerosis and myocardial infarction represent the major cardiovascular events. The interaction between these two clinical entities is based on direct mechanism mediated by systemic inflammatory response, leakage of cytokines and endothelial cells invasion by oral pathogens and indirect mechanism mediated by common risk factors or confounders.
It seems that tooth loss, periodontitis and poor oral hygiene increase the risk of atherosclerotic cardiovascular events, and subsequently oral health care professionals could contribute to public health cardiovascular control efforts.
牙科疾病、感染性心血管疾病与阻塞性心血管疾病之间的联系存在争议。
系统回顾文献，评估牙科疾病与心血管疾病发展之间的关联。
按照PRISMA指南，使用PubMed（医学索引）、科学网、Scopus、EMBASE和SciELO进行系统回顾。
在6680条记录中，经标题和摘要审查后，有82篇文章符合纳入标准。10项研究未观察到牙科疾病与心血管疾病之间的关联，而其余试验则提示存在潜在联系。牙齿缺失和牙周炎是主要评估的口腔状况，而冠状动脉疾病、中风、动脉粥样硬化和心肌梗死则是主要的心血管事件。这两种临床实体之间的相互作用基于由全身炎症反应介导的直接机制、细胞因子渗漏以及口腔病原体对内皮细胞的侵袭，以及由共同危险因素或混杂因素介导的间接机制。
牙齿缺失、牙周炎和口腔卫生不良似乎会增加动脉粥样硬化性心血管事件的风险，因此口腔保健专业人员可以为公共卫生心血管控制工作做出贡献。
