Umegaki K, Sano M, Suzuki K, Tomita I, Esashi T
Division of Applied Food Research, The National Institute of Health and Nutrition, Tokyo, Japan.
Bone Marrow Transplant. 1999 Jan;23(2):173-8. doi: 10.1038/sj.bmt.1701531.
Radiation-induced lipid peroxidation and its association with antioxidant vitamins in the bone marrow (BM), of rats subjected to total body irradiation (TBI) of X-rays at a dose of 3 Gy was investigated. The concentration of vitamin C in the BM decreased at 4 h, and reached about 2% of the control level at 24 h after irradiation. The concentration of vitamin E in the BM also decreased to 43% at 24 h. Corresponding to the decrease in vitamin E concentration, the concentration of 4-hydroxynonenal (HNE) in the BM increased 2.5-fold at 24 h. Similarly, increases in the concentrations of hexanal and thiobarbituric acid-reactive substances (TBA-RS) were detected in the BM. In the plasma, these parameters of lipid peroxidation were unchanged up to 48 h, but were increased at 96 h after irradiation. Four days of vitamin E administration to rats (p.o. 460 mg/kg body weight) prior to the 3 Gy X-irradiation increased the vitamin E concentration in the BM to 1.3-fold the control level, but did not attenuate the increases in HNE and hexanal in the BM. The slight accumulation of vitamin E in the BM as a result of the vitamin E treatment may be partly related to this lack of vitamin E effect.
研究了全身接受3 Gy X射线照射（TBI）的大鼠骨髓中辐射诱导的脂质过氧化及其与抗氧化维生素的关系。照射后4小时，骨髓中维生素C浓度降低，照射后24小时降至对照水平的约2%。骨髓中维生素E浓度在24小时时也降至43%。与维生素E浓度降低相对应，骨髓中4-羟基壬烯醛（HNE）浓度在24小时时增加了2.5倍。同样，在骨髓中检测到己醛和硫代巴比妥酸反应性物质（TBA-RS）浓度增加。在血浆中，这些脂质过氧化参数在照射后48小时内未发生变化，但在照射后96小时增加。在3 Gy X射线照射前给大鼠口服维生素E（460 mg/kg体重）4天，可使骨髓中维生素E浓度增加至对照水平的1.3倍，但并未减弱骨髓中HNE和己醛的增加。维生素E治疗导致骨髓中维生素E的轻微积累可能部分与维生素E缺乏效应有关。
