Endoh Kaori, Murakami Masahiro, Umegaki Keizo
Department of Domestic Science, Kyoritsu Women's University, Chiyoda-ku, Tokyo, Japan.
Int J Radiat Biol. 2007 Jan;83(1):65-71. doi: 10.1080/09553000601085972.
To examine how folate status in a body is influenced by oxidative stress.
Mice were given total body irradiation (TBI) by X-ray, and changes in the concentration of folate were compared to those in vitamins C and E.
In a time-dependent study, folate in plasma and bone marrow decreased from 5 h until 120 h post-TBI at 3 Gy. Folate in plasma and bone marrow decreased in a dose-dependent manner at 24 h. Marked decreases of vitamins C and E were also detected in bone marrow, but not in plasma even at 10 Gy of TBI. The susceptibility of plasma folate by irradiation was confirmed by an in vitro exposure study. Neither vitamins C and E nor folate were decreased in the liver by TBI.
It is suggested that folate is vulnerable to oxidative stress, and folate may need to be evaluated, particularly for TBI or radiotherapy.
研究体内叶酸状态如何受到氧化应激的影响。
对小鼠进行全身X射线照射（TBI），并将叶酸浓度的变化与维生素C和维生素E的变化进行比较。
在一项时间依赖性研究中，3 Gy全身照射后5小时至120小时，血浆和骨髓中的叶酸含量下降。24小时时，血浆和骨髓中的叶酸呈剂量依赖性下降。骨髓中维生素C和维生素E也显著下降，但即使在10 Gy全身照射时血浆中也未下降。体外暴露研究证实了照射对血浆叶酸的敏感性。全身照射并未使肝脏中的维生素C、维生素E和叶酸含量降低。
提示叶酸易受氧化应激影响，对于全身照射或放疗，可能需要对叶酸进行评估。
