乳腺癌和卵巢癌转移所致胸腔积液中1、3、6和11号染色体的变化。

Changes of chromosomes 1, 3, 6, and 11 in metastatic effusions arising from breast and ovarian cancer.

作者信息

Ioakim-Liossi A, Gagos S, Athanassiades P, Athanassiadou P, Gogas J, Davaris P, Markopoulos C

机构信息

Department of Pathology, Athens School of Medicine, University of Athens, Greece.

出版信息

Cancer Genet Cytogenet. 1999 Apr;110(1):34-40. doi: 10.1016/s0165-4608(98)00172-1.

DOI:10.1016/s0165-4608(98)00172-1

PMID:10198620

Abstract

This cytogenetic study deals with cell material obtained from 15 pleural fluids from 11 patients with breast cancer and 27 ascitic fluids from 16 patients with ovarian cancer; in addition, 8 pleural, 5 ascitic, and 1 pericardial fluid from patients with tuberculosis, liver cirrhosis, and heart insufficiency, were studied. Using mainly direct methods, as well as short-term cell cultures, the chromosome spreads were GTG-banded. Cancerous biopsies showed a plethora of numerical and structural chromosome anomalies and exhibited broad aneuploidy. Chromosomes participating more often in numerical and structural aberrations were 1, 3, 6, 7, 8, 9, 11, 12, and 17. This study provides further cytogenetic evidence for the involvement of these chromosomes in breast and ovarian malignancy.

摘要

这项细胞遗传学研究涉及从11例乳腺癌患者的15份胸液以及16例卵巢癌患者的27份腹液中获取的细胞材料；此外，还研究了来自结核病、肝硬化和心脏功能不全患者的8份胸液、5份腹液和1份心包液。主要采用直接法以及短期细胞培养，对染色体涂片进行GTG显带分析。癌组织活检显示大量的染色体数目和结构异常，并呈现广泛的非整倍体现象。更常参与数目和结构畸变的染色体为1、3、6、7、8、9、11、12和17号染色体。本研究为这些染色体参与乳腺癌和卵巢癌的发生提供了进一步的细胞遗传学证据。