Department of Surgery, The Oncology Institute 'Prof. Dr. Ion Chiricuta', 34-36 Republicii street, 400015 , Cluj-Napoca, Romania.
Department of Oncology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
J Ovarian Res. 2022 Jun 3;15(1):67. doi: 10.1186/s13048-022-01004-1.
Ovarian cancer is composed of a complex system of cells best described by features such as clonal evolution, spatial and temporal genetic heterogeneity, and development of drug resistance, thus making it the most lethal gynecologic cancer. Seminal work on cancer as an evolutionary process has a long history; however, recent cost-effective large-scale molecular profiling has started to provide novel insights coupled with the development of mathematical algorithms. In the current review, we have systematically searched for articles that focused on the clonal evolution of ovarian cancer to offer the whole landscape of research that has been done and highlight future research avenues given its characteristic features and connections to evolutionary biology.
卵巢癌由一个复杂的细胞系统组成，其特征最好用克隆进化、时空遗传异质性和耐药性发展等来描述，因此它是最致命的妇科癌症。癌症作为一个进化过程的开创性工作历史悠久；然而，最近具有成本效益的大规模分子分析开始提供新的见解，并结合数学算法的发展。在本综述中，我们系统地搜索了专注于卵巢癌克隆进化的文章，提供了已经完成的研究全景，并鉴于其特征和与进化生物学的联系，强调了未来的研究方向。
