Misawa S, Horiike S, Taniwaki M, Tsuda S, Okuda T, Kashima K, Abe T, Sugihara H, Noriki S, Fukuda M
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine.
Jpn J Cancer Res. 1990 Feb;81(2):148-52. doi: 10.1111/j.1349-7006.1990.tb02541.x.
The chromosomes were examined in cancerous effusions obtained from 7 patients with gastric cancer. In 1 patient, the modal chromosome number was 46 with a normal chromosome complement in the majority of the cells examined. The other 6 patients revealed numerical and structural aberrations. Among the structural rearrangements detected, chromosome 3 was involved in the short arm and in the long arm, each in three patients; bands p25, q21, q23, and q27 were recurrently involved and a band q23 was lost in 3 patients. Rearrangements of chromosome 5 in the long arm and of chromosome 17 at or near the centromere were also observed in three patients each. Gains of chromosome 7 was seen in 5 patients and of chromosome 13 in 4. Some of these alterations may be specific for gastric cancer.
对7例胃癌患者的癌性积液中的染色体进行了检查。1例患者的众数染色体数为46，在所检查的大多数细胞中染色体组正常。其他6例患者出现了数量和结构异常。在所检测到的结构重排中，3号染色体短臂和长臂均有涉及，各有3例患者；p25、q21、q23和q27带反复出现异常，3例患者中q23带缺失。5号染色体长臂和17号染色体着丝粒处或附近的重排也分别在3例患者中观察到。5例患者出现7号染色体增多，4例出现13号染色体增多。其中一些改变可能是胃癌特有的。
