Tulbah A, Al-Dayel F, Fawaz I, Rosai J
Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Am J Surg Pathol. 1999 Apr;23(4):473-6. doi: 10.1097/00000478-199904000-00013.
We report an unusual case of multifocal leiomyosarcoma involving the thyroid gland, liver, and right lung in a child with congenital immunodeficiency disease. The smooth muscle nature of these neoplasms was confirmed by immunohistochemistry and electron microscopic studies. In situ hybridization showed large amounts of Epstein-Barr virus messenger RNA within the tumor cells. Although Epstein-Barr virus-associated smooth muscle tumors have been reported in children with AIDS and after organ transplantation, we are unaware of any case report in congenital immunodeficiency disease.
我们报告了一例罕见的多灶性平滑肌肉瘤病例，该病例发生在一名患有先天性免疫缺陷疾病的儿童身上，肿瘤累及甲状腺、肝脏和右肺。通过免疫组织化学和电子显微镜研究证实了这些肿瘤的平滑肌性质。原位杂交显示肿瘤细胞内有大量的爱泼斯坦-巴尔病毒信使核糖核酸。虽然在艾滋病儿童和器官移植后曾报告过与爱泼斯坦-巴尔病毒相关的平滑肌肉瘤，但我们尚未知晓有任何关于先天性免疫缺陷疾病的病例报告。
