成人人类免疫缺陷病毒感染患者喉的 Epstein-Barr 病毒相关性平滑肌肉瘤：病例报告及文献复习。
Epstein-Barr virus-associated leiomyosarcoma of the larynx in an adult patient with human immunodeficiency virus infection: Case report and review of the literature.
机构信息
Department of Infection, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou City, P.R. China.
Department of Otolaryngology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou City, P.R. China.
出版信息
Head Neck. 2022 Dec;44(12):2886-2903. doi: 10.1002/hed.27184. Epub 2022 Sep 7.
We investigated the clinical features, treatment, and prognosis of laryngeal leiomyosarcoma (LLMS) and Epstein-Barr virus-associated (EBV-associated) LMS. We report a case of EBV-associated LLMS in an adult patient with HIV infection. We also conducted a review of the English-language literature on LLMS and EBV-associated leiomyosarcoma. To the best of our knowledge, 62 cases of LLMS and EBV-associated leiomyosarcoma have been reported to date. Of patients with LLS, 18.9% had distant metastases and 17.0% had local recurrence. The overall 5-year survival rate was 64.0%. Distant metastases affected the survival of patients with LLMS (p = 0.04). EBV-positive patients had a low survival rate (p = 0.01). Among patients with EBV-associated LMS, 8.2% had distant metastases and recurrence and the overall 5-year survival rate was 50.0%. EBV-associated LLMS is rare. The EBV infection might be a poor prognostic factor of LLMS.
我们研究了喉平滑肌肉瘤（LLMS）和 Epstein-Barr 病毒相关（EBV 相关）平滑肌肉瘤的临床特征、治疗和预后。我们报告了一例成人 HIV 感染患者的 EBV 相关 LLMS 病例。我们还对英文文献中关于 LLMS 和 EBV 相关平滑肌肉瘤的文献进行了回顾。据我们所知，迄今为止已经报道了 62 例 LLMS 和 EBV 相关平滑肌肉瘤病例。在 LLS 患者中，18.9%有远处转移，17.0%有局部复发。总体 5 年生存率为 64.0%。远处转移影响 LLMS 患者的生存（p=0.04）。EBV 阳性患者的生存率较低（p=0.01）。在 EBV 相关 LMS 患者中，8.2%有远处转移和复发，总体 5 年生存率为 50.0%。EBV 相关 LLMS 较为罕见。EBV 感染可能是 LLMS 的预后不良因素。
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