Leonsson M, Oscarsson J, Bosaeus I, Lundgren B K, Johannsson G, Wiklund O, Bengtsson B A
Research Center for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden.
J Clin Endocrinol Metab. 1999 Apr;84(4):1296-303. doi: 10.1210/jcem.84.4.5611.
An increased dietary load of cholesterol (ch) and saturated fat increases serum low density lipoprotein ch (LDL-ch) levels. GH therapy in GH-deficient adults decreases serum LDL-ch levels. In the rat, GH is important for resistance to dietary cholesterol in terms of serum cholesterol levels. The aim of this study was to investigate the influence of GH on the effects of an increase in the intake of cholesterol and saturated fat on serum lipoproteins and markers for cholesterol synthesis in man. Six GH-deficient adults were given an isocaloric diet enriched in cholesterol and saturated fat for 17 days with and without GH therapy (1-1.5 U/day). Serum cholesterol, LDL-ch, apolipoprotein B (apoB), and apoA1 levels increased during the diet period with GH therapy and tended to increase during the diet period without GH. However, GH therapy did not influence the dietary effect on serum cholesterol, LDL-ch, apoA1, or apoB levels. Serum levels of triglycerides, very low density lipoprotein ch, high density lipoprotein ch, and apoE were not affected by diet or GH therapy. GH therapy increased serum lipoprotein(a) levels, but did not affect the response to diet. The serum total delta7-lathosterol/cholesterol ratio increased less during the diet period with GH therapy than during the diet period without GH. Serum 7alpha-hydroxy-4-cholesten-3-one levels tended to increase during both diet periods, but were not influenced by GH treatment. Serum plant sterol levels did not change. These results indicate that GH counteracts an increase in cholesterol synthesis induced by a high fat diet without affecting bile acid synthesis or sterol absorption. GH therapy did not have any major influence on the dietary effects on serum lipoprotein levels.
饮食中胆固醇（ch）和饱和脂肪负荷增加会使血清低密度脂蛋白胆固醇（LDL-ch）水平升高。对生长激素缺乏的成年人进行生长激素（GH）治疗可降低血清LDL-ch水平。在大鼠中，就血清胆固醇水平而言，GH对于抵抗饮食中的胆固醇很重要。本研究的目的是调查GH对增加胆固醇和饱和脂肪摄入量对人体血清脂蛋白及胆固醇合成标志物影响的作用。6名生长激素缺乏的成年人接受了富含胆固醇和饱和脂肪的等热量饮食，为期17天，期间有或没有GH治疗（1 - 1.5 U/天）。在接受GH治疗的饮食期间，血清胆固醇、LDL-ch、载脂蛋白B（apoB）和apoA1水平升高，在未接受GH治疗的饮食期间这些指标也有升高趋势。然而，GH治疗并未影响饮食对血清胆固醇、LDL-ch、apoA1或apoB水平的作用。血清甘油三酯、极低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和apoE水平不受饮食或GH治疗影响。GH治疗使血清脂蛋白（a）水平升高，但不影响对饮食的反应。与未接受GH治疗的饮食期间相比，接受GH治疗的饮食期间血清总δ7-羊毛甾醇/胆固醇比值升高幅度较小。在两个饮食期间血清7α-羟基-4-胆甾烯-3-酮水平均有升高趋势，但不受GH治疗影响。血清植物甾醇水平未发生变化。这些结果表明，GH可抵消高脂饮食诱导的胆固醇合成增加，而不影响胆汁酸合成或甾醇吸收。GH治疗对饮食对血清脂蛋白水平的影响没有任何重大作用。
