Matsuoka S, Nakagawa R, Nakayama H, Yamashita K, Kuroda Y
Department of Pediatrics, Tokushima Municipal Hospital, Japan.
Pediatr Int. 1999 Feb;41(1):46-51. doi: 10.1046/j.1442-200x.1999.01011.x.
Our objective was to investigate the influence of parental allergy on the manifestations and course of allergic disease in children.
A total of 15,234 school children aged 6 and 9 years were evaluated by means of questionnaires completed by their parents in a cross-sectional survey conducted in Tokushima, Japan. The prevalence and relative risk ratio (RRR) for parental allergy in children with atopic dermatitis, asthma and allergic rhinitis were 6.4% (RRR 2.5), 3.2% (RRR 2.4) and 15% (RRR 2.4), respectively. The risk of atopic dermatitis was particularly high in children whose parent had atopic dermatitis, with an RRR of 2.8 (father) and 3.7 (mother). Children with a parental history of asthma also had a high risk of that disorder (RRR of father 5.3, mother 6.2). However, the risk of allergic rhinitis was no different in children with a parental history of allergic rhinitis or from children with a parental history of asthma and atopic dermatitis. A history of allergic disease in both parents, especially of asthma and atopic dermatitis, increased the risk of allergic disease in the child. Milder symptoms, such as wheezy bronchitis, in schoolchildren were similarly related with the same hereditary tendency as the identical allergic disease. The disappearance of allergic symptoms with age also related to a hereditary component, being less likely in children with a history of parental allergy than in those without such an atopic history.
The manifestations and course of allergic disease in school children relate to parental allergic disease.
我们的目的是研究父母过敏对儿童过敏性疾病的表现及病程的影响。
在日本德岛进行的一项横断面调查中，通过由父母填写的问卷对总共15234名6至9岁的学童进行了评估。患有特应性皮炎、哮喘和过敏性鼻炎的儿童中父母过敏的患病率及相对风险比（RRR）分别为6.4%（RRR 2.5）、3.2%（RRR 2.4）和15%（RRR 2.4）。父母患有特应性皮炎的儿童患特应性皮炎的风险尤其高，父亲患特应性皮炎时RRR为2.8，母亲患特应性皮炎时RRR为3.7。有哮喘家族史的儿童患该疾病的风险也很高（父亲RRR为5.3，母亲RRR为6.2）。然而，有过敏性鼻炎家族史的儿童与有哮喘和特应性皮炎家族史的儿童患过敏性鼻炎的风险并无差异。父母双方都有过敏性疾病史，尤其是哮喘和特应性皮炎史，会增加儿童患过敏性疾病的风险。学童中较轻的症状，如喘息性支气管炎，与相同的遗传性倾向相关，如同相同的过敏性疾病一样。随着年龄增长过敏症状的消失也与遗传因素有关，有父母过敏史的儿童比没有这种特应性病史的儿童更不容易出现症状消失的情况。
学童过敏性疾病的表现及病程与父母的过敏性疾病有关。
