气道表面液体“薄膜”生理学的分子见解。
Molecular insights into the physiology of the 'thin film' of airway surface liquid.
作者信息
Boucher R C
机构信息
Cystic Fibrosis/Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7248, USA.
出版信息
J Physiol. 1999 May 1;516 ( Pt 3)(Pt 3):631-8. doi: 10.1111/j.1469-7793.1999.0631u.x.
Abstract
The epithelia that line the airways of the lung exhibit two general functions: (1) airway epithelia in all regions 'defend' the lung against infectious and noxious agents; and (2) airway epithelia in the proximal regions replenish water lost from airway surfaces, i.e. the 'insensible water loss', consequent to conditioning inspired air. How airway epithelia perform both functions, and co-ordinate them in health and disease, is the subject of this review.
摘要
衬于肺气道的上皮细胞具有两种主要功能
（1）所有区域的气道上皮细胞“保护”肺免受感染性和有害物质的侵害；（2）近端区域的气道上皮细胞补充因调节吸入空气而从气道表面流失的水分，即“不显性失水”。气道上皮细胞如何执行这两种功能，以及在健康和疾病状态下协调这些功能，是本综述的主题。
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