Hallson P C, Rose G A
Br J Urol. 1978 Dec;50(7):442-8. doi: 10.1111/j.1464-410x.1978.tb06188.x.
Rapid evaporation of urine to osmolarity 1200 results in a high incidence of envelope Wedellite and calcium phosphate crystals. The Wedellite crystals closely resemble those seen in untreated urine samples of stone formers. The incidence of crystalluria produced by these tests is higher in the stone formers than in the normal subjects, reduced by thiazides and increased by cellulose phosphate; combined thiazide and cellulose phosphate therapy was most effective in reducing crystalluria. Simple calcium and oxalate concentration products were calculated and did not correlate well with incidence of calcium oxalate crystalluria. Although the product is important, inhibitors of crystal formation must be equally important. It is postulated, but not proven, that the evaporation tests may indicate normal subjects at risk to stone formation when exposed to chronic dehydration and whether a stone former is still metabolically active.
尿液快速蒸发至渗透压1200会导致包膜水草酸钙和磷酸钙晶体的高发生率。水草酸钙晶体与结石形成者未经处理的尿液样本中所见的晶体非常相似。这些测试产生的结晶尿发生率在结石形成者中高于正常受试者，噻嗪类药物可降低其发生率，而磷酸纤维素可增加其发生率；噻嗪类药物和磷酸纤维素联合治疗在减少结晶尿方面最有效。计算了简单的钙和草酸盐浓度乘积，其与草酸钙结晶尿的发生率相关性不佳。虽然该乘积很重要，但晶体形成抑制剂肯定同样重要。据推测（但未得到证实），蒸发测试可能表明正常受试者在暴露于慢性脱水时存在结石形成风险，以及结石形成者是否仍处于代谢活跃状态。
