LeMosy E K, Hong C C, Hashimoto C
Dept of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA.
Trends Cell Biol. 1999 Mar;9(3):102-7. doi: 10.1016/s0962-8924(98)01494-9.
The dorsoventral axis of the Drosophila embryo is determined by a spatial cue generated by ovarian somatic cells. This cue is communicated to the embryo through an extracellular serine protease cascade active only on the ventral side of the embryo. Studies of the proteases and somatically expressed proteins involved in this signalling process suggest a working model for how the protease cascade is locally activated hours after the ovarian somatic cells have degenerated.
果蝇胚胎的背腹轴由卵巢体细胞产生的空间信号决定。该信号通过仅在胚胎腹侧活跃的细胞外丝氨酸蛋白酶级联传递给胚胎。对参与这一信号传导过程的蛋白酶和体细胞表达蛋白的研究，提出了一个关于在卵巢体细胞退化数小时后蛋白酶级联如何被局部激活的工作模型。
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