COP1在拟南芥光形态建成发育抑制中的作用。

The role of COP1 in repression of Arabidopsis photomorphogenic development.

作者信息

Osterlund M T, Ang L H, Deng X W

机构信息

Dept of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520-8104, USA.

出版信息

Trends Cell Biol. 1999 Mar;9(3):113-8. doi: 10.1016/s0962-8924(99)01499-3.

DOI:10.1016/s0962-8924(99)01499-3

PMID:10201077

Abstract

Photomorphogenic development in Arabidopsis is regulated by the key repressor COP1, which interacts with specific transcription factors in the nucleus to modulate their activities. In the dark, COP1 accumulates in the nucleus and represses photomorphogenic development. Light diminishes the nuclear accumulation of COP1 and abrogates its repressor activity. A number of cellular components are involved in light-dependent nucleocytoplasmic partitioning of COP1, including the multisubunit COP9 complexes and at least three well-characterized photoreceptors. This review discusses current understanding of the mechanisms of COP1 action.

摘要

拟南芥中的光形态建成发育受关键阻遏因子COP1调控，COP1在细胞核中与特定转录因子相互作用以调节其活性。在黑暗中，COP1在细胞核中积累并抑制光形态建成发育。光会减少COP1在细胞核中的积累并消除其阻遏活性。许多细胞成分参与了COP1依赖光的核质分配，包括多亚基COP9复合体和至少三种已被充分表征的光感受器。本文综述了目前对COP1作用机制的理解。